Borderlands 4 Best Builds

In Borderlands 4 best builds matter just as much as picking your Vault Hunter. Your build decides whether you can truly reach your full potential. In this guide, we’ll go over the top builds for leveling, endgame, solo play, and team runs. We’ll also break down the best build for each character so you can enjoy the game without second-guessing your choices.

Borderlands 4 Best Builds Key Takeaways:

• The best Borderlands 4 leveling builds are Kinetic Crit Phamiliar Vex, Cryo Ordnance Phamiliar Vex, Radiation Harlowe, and Cannon/Peacebreaker Rafa;
• For Borderlands 4 endgame, top choices include One Shot Infinite Kills Rafa, Kill Skill Dead Ringer Vex, Blood Witch Incarnate Vex, Neutron Capture Spam Harlowe, and Forgefall Amon;
• The strongest Borderlands 4 solo builds are Infinite Ammo Rafa, Bloody Reaper Vex, Energy Vampire Vex, and Nuclear Winter Harlowe;
• In Borderlands 4 teamplay, Bleed + Sacrifice Vex, Gun Damage Incarnate Vex, Infinite Arc-Knives Rafa, and Gamma Burst Trouble Vex stand out as the best.

📌 We’ll add the Borderlands 4 Builds Tier List after release, once the meta is more settled.

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Borderlands 4 Best Leveling Builds

These are the best Borderlands 4 builds for leveling that allow smooth and fast progression. Some of them are prepared for safe play, others are tailored for aggressive fights. Use one of the following top-tier builds to Level Up easily, or ask our team to do it even faster.

Kinetic Crit Phamiliar Vex

The best build for leveling in Borderland 4 right now is the Kinetic Crit Phamiliar Vex. This build relies heavily on the Phase Phamiliar companion and piles critical hit chance and damage. Thanks to this combination, Vex feels very easy to level up, even if you play solo.

By combining high-fire-rate weapons with crit bonuses, Vex tears through enemies while leveling, so the process is a piece of cake. You receive excellent mob clear speed and scaling damage, though the build loses a little survivability in favor of raw DPS.

Cryo Ordnance Phamiliar Vex

Cryo Ordnance Phamiliar is another Vex leveling build that combines the Phamiliar with damage, Cryo in this case. It allows you to freeze mobs and adds more great control.

The build also scales with kill skills and elemental bonuses, so you can lock down and shatter groups in no time. What you’ve got here is consistent crowd control and decent survivability since frozen enemies don’t hit back that much. All in all, a great choice for safe leveling without sacrificing a lot of damage. You can level up solo or with a team; the build is perfect in both cases.

Radiation Leveling Harlowe

Radiation Leveling Harlowe build focuses on Radiation status effects. It means that your weapons and skills spread radiation damage over time, while the CHROMA Accelerator gives bursts of AoE.

The main advantage of the build is consistent DoT output, effective against both single targets and packs. It’s a forgiving build that doesn’t rely on gear and works well throughout the campaign, so you can level up even without a team by your side.

Cannon Leveling Rafa

Cannon Leveling build uses Rafa’s Cannon and Overdrive synergy to offer ongoing gun damage. Also, key skill nodes increase weapon damage, fire rate, and mobility, which keeps you mobile in the field.

In a word, you gain consistent DPS and smooth gunplay that finishes missions quickly. It is an easy-to-use, powerful option for players who prefer classic run-and-gun gameplay. No need to hide or plan your attacks.

Peacebreaker Cannons DPS Focused Rafa

Peacebreaker Cannons DPS Focused Rafa builds around the Peacebreaker Cannons tree for a more aggressive leveling route. Thanks to red and blue skill trees, you have access to buffs to gun handling, cooldowns, and cannon performance.

The result is high sustained damage with enough survivability to power through tougher fights. It’s a strong, consistent choice if you want both power and reliability.

Borderlands 4 Best End Game Builds

Choose one of these best Borderlands 4 builds for endgame to dominate the most challenging content. S-tier builds will have you prepared for any type of situation, giving you tons of damage, mobility, or survivability, or 3-in-1.

One Shot Infinite Kills Rafa

One Shot Infinite Kills Rafa’s most aggressive endgame build. The idea behind it is simple: stack cannon and ordnance damage until every shot one-shots packs.

With cooldown resets and Overdrive uptime, you can sustain the damage indefinitely. It’s a traditional glass cannon build for speedruns and melting bosses fast, so it’s better to use it with a reliable tanky teammate by your side. Best for boss farming and speedrunning.

Kill Skill Dead Ringer Vex

Kill Skill Dead Ringer build synergizes with Vex’s Kill Skill chains. Every takedown feeds your crit bonuses, reload speed, and damage snowballing.

In endgame content, it performs well at turning any encounter into a momentum run, but requires aggressive play to keep up buffs. In a nutshell, it’s a good pick for players who prefer non-stop action over planned runs. Best for nonstop mob clearing.

Blood Witch Incarnate Vex

Blood Witch Incarnate is a darker version of Vex that stacks elemental and life-steal effects. The main advantage is that the Incarnate tree offers sustainability with vampiric damage, and kill skills pile up raw power.

As a result, you’re left with high DPS and self-healing that makes it safer for harder content. The build offers a great balance of damage and survivability for end-game, so you can also safely play solo. Best for survivability with high DPS.

Neutron Capture Spam CHROMA Accelerator Harlowe

Harlowe’s best endgame build, Neutron Capture Spam CHROMA Accelerator, is all about spamming CHROMA Accelerator for AoE nukes, obviously. With skill tree nodes that buff cooldowns and elemental spread, you put down constant bursts that annihilate groups.

To sum up, it’s a flashy, high-damage build that clears mobs quickly, but it needs attentive energy management in longer fights. It’s recommended for skilled players who are experienced in this playstyle. Best for AoE burst damage.

Forgefall Crucible Amon

Amon goes hard on ordnance with the Forgefall Crucible build, stacking Crucible skills for massive explosive bursts. The build is all about blowing up chain reactions and zoning with area damage.

It’s slower than crit-based builds, but it’s wonderfully consistent in co-op or wave-heavy combat. So, Forgefall Crucible Amon is a good option if you need consistent firepower that doesn’t depend on weapon RNG. Best for consistent explosive damage in co-op.

Borderlands 4 Best Solo Play Builds

If you prefer to play without a team, these Borderlands 4 builds for solo play are your go-to options. Use one of the best solo builds to survive in the toughest combats and clear mobs like it’s a piece of cake.

Infinite Ammo Rafa

Infinite Ammo build turns Rafa into a walking turret by stacking skills for lower reload times and increased ammo regen. The general idea is to make your guns fire constantly, so you can get things done quickly without worrying about running out of ammo.

You’ll notice smoother pacing since downtime is almost gone, and it works well with most common weapons. It’s an extremely simple but extremely effective option for solo players who want always-available firepower and minimal resource management.

Infinite Lance Rafa

The Infinite Lance setup is centered on the Apophis Lance, with cooldown resets so the skill is always kept on cooldown for almost every situation. The result is huge single-target damage spikes that can melt down bosses or elites in mere seconds.

You sacrifice some sustain compared to other setups, but the raw firepower makes it one of the finest solo boss-killers. It’s a great choice for players who prefer heavy-hitting abilities over steady gunplay.

Overdrive Stacking Rafa

Overdrive Stacking caps Rafa’s scaling by constantly activating his Overdrive ability. Each activation increases weapon damage and movement speed, and it can snowball you into the late game.

In solo play, it allows you the freedom of becoming more and more powerful the longer you remain alive, typically overwhelming enemies with momentum. It appeals to the player who enjoys battles where the player’s strength just keeps climbing and never tops too soon.

Gun Damage Bleed Vex

Gun Damage Bleed pairs increased weapon damage with bleed damage that continues to hurt enemies even while you reload or reposition yourself. It puts your DPS into a normal state where soloing for longer periods isn’t too merciless if you miss a chance for a burst window.

The build complements best with quick-firing weapons such that bleed stacks always tickle. It is a reliable, hard-hitting solo selection that puts pressure without calling for crit streaks.

Bloody Reaper Vex

Bloody Reaper offers the Reapers’ aggro and adds sustain with life-steal gameplay. Not only do you receive an increase to your damage output per kill and crit, but you also recover health, making solo survival much simpler.

It allows you to drop into difficult encounters without having to use consumables. It provides both high-DPS and internal healing with the best of both worlds.

Energy Vampire Vex

Energy Vampire is all about endurance, stacking elemental triggers, and life-steal to turn damage into healing. You’re constantly healing back massive chunks of health while eroding enemies, making solo content significantly safer.

The damage doesn’t spike as high as crit-focused builds, but the ability to outlast fights is unmatched. It’s a safer option if you don’t prefer risky damage setups.

Ice Queen Harlowe

Ice Queen relies on Cryo effects to freeze up enemies, giving you total control of the battlefield. Frozen enemies will deal little to no damage back, so you can fight clusters without being overwhelmed.

The build is easy to handle and doesn’t need to rely on rare gear, making it ideal for solo running through the story. It’s a control, defensive playstyle that pays off with patience and positioning.

Nuclear Winter Harlowe

Nuclear Winter builds on Harlowe’s Cryo strengths by adding explosive AoE bursts to frozen groups. You retain the security of freezes, but now have enemies falling much quicker due to area damage combos.

It’s aggressive but secure, allowing you to clear groups quickly without losing control. For solo players who need crowd control and massive damage simultaneously, it’s one of the best options.

Borderlands 4 Best Teamplay Builds

Teamplay in Borderlands 4 is all about fun and quick takedowns. These Borderlands 4 best builds for team play will have you prepared to work in a group and assist your teammates in every possible way. No group by your side? No problem, our Pro Players will assist you and fight or farm with you.

Bleed + Sacrifice Incarnate Vex

The Bleed + Sacrifice Incarnate accumulates bleed effects and Crit through Vex’s Incarnate tree and gives up some survivability for pure team damage. Additionally, she gains bonus Kinetic Damage with guns when full on HP, which is easy to achieve in a team.

It is good in a group since support members can absorb aggro while you simply constantly apply bleed stacks and deal damage. The hidden power is sustained DPS that covers for burst-heavy teammates.

Gun Damage Incarnate Vex

Here, Vex again relies on the raw gun damage of the Incarnate tree without requiring too much pet or bleed. The build increases crit chance, reload speed, and weapon handling, making her a stable team-fight ranged DPS.

That’s one of the top benefits of the Drink Full passive, which enables you to reap even more rewards from the gun damage and boost your fire rate. You will provide consistent firepower that is straightforward and effortless to maintain as allies dominate the field. It’s a classic, effortless setup that keeps your throughput high throughout extended missions.

Kill Skill Incarnate Vex

Kill Skill Vex is designed for fast kill fights where enemies die quickly. The build relies on the Energy Vampire Augment that grants the Kill Skill effect: killing enemies with active Incarnate stacks Energy Vampire, and increases your damage drastically.

With a team, you excel if teammates create conditions for easy killing hits. This build is great for situations where the battle never ends. Especially if you can fire non-stop.

Infinite Arc-Knives Rafa

Rafa’s Arc-Knives build is all about splash damage with group clears or taking out multiple enemies at once. With increased chain damage and throw speed, you offer both melee AoE pressure and precision assistance to your teammates.

In co-op, this build is unstoppable, as you can easily thin crowds or help finish priority targets. The strength of the build is overall deadliness: high damage with short cooldowns.

Gamma Burst Trouble Vex

Gamma Burst Trouble teamplay build uses Vex’s pet, Trouble, with Gamma Burst effects for team explosion damage. Trouble is both a distraction and AoE source, and your build basically burns everyone out with radiation.

The build performs well in co-op because your pet can soak while allies deal damage elsewhere. The value of the build is to bring strong damage over time and assist your team.

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Overall, we’ve covered all the top Borderlands 4 best builds, including the most popular choices for leveling and endgame. Solo players can find the perfect setup for themselves, while teams can pick strong builds that shine in co-op play. While the tier list is subject to change, keep an eye on our guides to stay updated.